Endocrine Abstracts

It has long been recognised that caloric restriction extends lifespan in a broad range of organisms from nematodes to rodents. Furthermore, it has also been demonstrated that manipulation of components of the insulin and Igf1 signalling pathway also increases lifespan. These findings were initially made in C. elegans and Drosophila but more recently these observations have been extended to rodents. However, the processes underlying the alterations in lifespan see...